MA03 TE Mirinov
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چکیده
most fundamental mechanism in the origin of life and the evolution of complex biological organization, manifests itself at all scales in living systems. To grasp a specific biological structure, we must be able to disassemble and reassemble it. Only by demonstrating our ability to do so can we claim that our understanding of the rules and principles governing the functioning of tissues and organs is complete. Up to now the main direction in tissue engineering was based on using biodegradable scaffolds as spatial support for the assembly of isolated cells into tissues. It was assumed that the scaffold would provide the right conditions to engineer organs with desired shape and mechanical properties. Seeded cells would proliferate, produce extracellular matrix, and eventually replace the scaffold to form living tissues or organs. This process is long, and cell survival may be an issue. Self-assembling cell aggregates may provide a better starting point and faster organ formation. Such aggregates are already a popular tool for studying cell adhesion, cell sorting, and tumor growth, and they also have been used in drug testing. It recently was suggested to use cell aggregates to build tissue-engineered cartilage, retina, liver, and other organs. An intriguing idea is to employ cell aggregates as building blocks in the emerging technology of organ printing. Organ printing is an application of rapid prototyping or computer-aided layer-by-layer deposition in tissue engineering. Instead of seeding isolated cells, aggregates could be printed directly on the surface of stimuli-sensitive gels. Addition of another layer of gel is followed by the printing of another layer of aggregates and so on. After fusion of aggregates, tissue constructs of the desired geometry may be formed. The gel is subsequently eliminated.
منابع مشابه
Association of transpiration efficiency with N2 fixation of peanut under early season drought
Peanut is grown mostly in rainfed areas where drought is a recurring problem. Peanut genotypes with high transpiration efficiency (TE) use less water and produced yield better under drought conditions. Specific leaf area and SPAD chlorophyll meter reading are used as surrogate traits for TE. N2 fixation (NF) is also used as a surrogate trait for yield under drought. The objective of this study ...
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Background: Recent theranostic (therapeutic or diagnostic) applications of tellurium nanoparticles have attracted a great interest for development of different methods for synthesis of this valuable nanostructure, especially via biological resources. Objectives: In the present study, the antimicrobial and antioxidant effects of the tellurium nanorods (Te NRs) biosynthesized by a bacterial...
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Background: Trichoepithelioma (TE) is a benign skin tumor with follicular differentiation, which sometimes is difficult to distinguish clinically and histologically from cutaneous basal cell carcinoma (BCC). An accurate diagnosis of these lesions is essential for effective and appropriate therapeutic decisions. Therefore, several attempts have been made to identify immunohistochemical differenc...
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Testosterone enanthate (TE) is used by many athletes as a muscle builder. Previous studies showed that high concentration of the drug in plasma may affect the natural function of endocrine glands, specially the secretion of the adrenocortical hormones. The objective of the present study was to examine the effects of high concentration of TE on histometrical structure of adrenal cortex in male r...
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